Abstract: OBJECTIVE: To investigate the expression of c-IAP2，Bcl-2，STAT3，cyclinD1，PTEN， VEGF associated with apoptosis -ralated gene Survivin in Kazak’s esophageal carcinoma tissues and its adjacent non-carcinoma tissues and to find relationships between Survivin and the above six genes. METHODS：RT-PCR was used to detect the expressions of these six genes in carcinoma tissues and its adjacent non-carcinoma tissues in 32 Kazaks esophageal cases，Western-bolt performed to evaluate the levels of proteins. RESULTS：In Xinjiang Kazak's esophageal cancer，The expression rates of these six genes in 32 cases were over 50.0％，with c-IAP2 at 93.75%，cyclinD1 at 87.5%，VEGF at 84.38%. The expression levels of c-IAP2 STAT3 PTEN and VEGF were significantly increased in carcinoma compared to the adjacent non-carcinoma tissues(P<0.05). There were differences in the expressions of c-IAP2，STAT3，PTEN and VEGF mRNA between carcinoma and its adjacent non-carcinoma tissues (P<0.05). PTEN and VEGF showed similar expression status in the level of transcription and translation. There were correlations between Survivin and c-IAP2，STAT3，PTEN and VEGF expressions in carcinoma tissues (P<0.05). We found that the expression of cyclinD1 correlated with c-IAP2，Bcl-2 and PTEN mRNA；and the expression of PTEN correlated with c-IAP2， TAT3， cyclinD1 and VEGF mRNA (P<0.05). Expression of cyclinD1 correlated with differentiated degree and stage；the expression of Bcl-2 and STAT3 correlated with lymph node metastasis whilst the expression of VEGF correlated with sex，lymph node metastasis (P<0.05). CONCLUSION：Survivin played an important role in promoting carcinogenesis and development of esophageal cancer in Kazak's，through regulating apoptosis，cell cycle and angiogenesis. These six genes could be identified as molecular markers for early diagnosis，and prognosis prediction in Xinjiang Kazak's esophageal cancer.

Key words: Xinjiang Kazak's esophageal cancer, Survivin, apoptosis, cell cycle, angiogenesis